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Mechanism of HDAC inhibitor TSA in osteogenic differentiation of hPDLCs. TSA inhibits HDAC enzymes, including the reduction of HDAC1, 2, 3 leading to the acetylation of H3K9K14 and production and acetylation of RUNX2 and which activate bone-related gene expression. Then, the cells go to osteogenesis (H3: Histone H3; K9, K14: Lysine 9, 14) (Huynh et al., 2016, Huynh et al., 2017).
