Table 1.
Summary of Zn2 +-dependent HDACs subfamilies. SM—skeletal muscle; B—brain; PL—platelet; L—liver; K—kidney; S—spleen; H—heart; PA—pancreas.
| HDAC | Localization | Major tissue distribution | Function (partly) |
|---|---|---|---|
| Class I | |||
| HDAC 1 | Nucleus | Ubiquitous | Transcriptional repression Cell survival, proliferation and differentiation |
| HDAC 2 | |||
| HDAC 3 | |||
| HDAC 8 | Suppress osteogenic differentiation | ||
| Class IIa | |||
| HDAC 4 | Nucleus/cytoplasm | H, SM, B | Transcriptional repression Chondrocyte and osteocyte development differentiation |
| HDAC 5 | Transcriptional repression Muscle differentiation block Cardiac and vascular endothelial function |
||
| HDAC 7 | H, PL, PA, SM | Inhibit osteoclast differentiation Thymocyte differentiation |
|
| HDAC 9 | SM, B | ||
| Class IIb | |||
| HDAC 6 | Mainly cytoplasm | H, L, K, PA | Tubulin-deacetylase |
| HDAC 10 | L, S, K | Unknown | |
| Class IV | |||
| HDAC 11 | Nucleus/cytoplasm | B, H, SM, K | Immuno-regulation |
(Modified from Suzuki (2009) and Marks (2010))