Fig. 1.

Schematic representation of changes in transcription factors binding to SNPs located in the promoter of the osteopontin gene. At the top of the image there is a representation of the SNPs located in the osteopontin promoter that have been linked to variation in cancer risk in the carriers. The position of each SNP is given with respect to the transcription starting point. Below, for each SNP, the binding of the transcription factors and changes associated with altered genotype are exemplified.