Fig. 6.

Intracellular redox changes induced by 13 and 15 on bloodstream T. b. brucei. Two million parasites were exposed to 0.54 μM 13, 1.49 μM 15, 78 nM suramin, 25 μM menadione, 1 mM DTT or left untreated (vehicle, 1% v/v DMSO) for 4 h (black bars) and then treated for 15 min with 1 mM DTT (grey bars). The values are expressed as percentage (±SD) reduction of the biosensor relative to the control condition with DMSO without added DTT (n = 3). Statistical analysis was performed applying One Way ANOVA test followed by Dunnet's multiple comparisons posttest. ***, ** and * denote differences with p values < 0.001, <0.01 and < 0.5, respectively, vs DMSO control.