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. 2017 Aug 12;7(3):303–313. doi: 10.1016/j.ijpddr.2017.08.001

Fig. 8.

Fig. 8

a) 1H,77Se multiple-bond CPMG-HSQMBC correlation spectrum of a solution of 13 in 1:1 DMSO-d6: phosphate buffer (100 mM in D2O, pH 7.0) and glutathione in 1:4 M ratio reveals 1H,77Se coupling connectivities between selenium and the cysteine β-protons (A, B) of glutathione. b) Structure of selenenylsulfide 20 highlighting crucial 1H,77Se coupling connectivities. Shown above the 2D map is the 1H NMR spectrum with indications of the relevant protons in b). The 77Se spectrum (on the left of the 2D map) provides further confirmation for the structure of 20via a distinctly different 77Se chemical shift with respect to that in 13 (δSe 483 ppm in 20vs. 400 ppm in 13).