Table 2.
Pre-treatment IVIM average and histogram metric median (min, max) values between RECIST responders and non-responders. Raw and adjusted p-values for Wilcoxon rank-sum test comparing responders to non-responders are given, with significant group differences in bold.
| Overall (N = 32) | Responders (N = 27) | Nonresponders (N = 5) | p | adj. p | ||
|---|---|---|---|---|---|---|
| ADC (μm2/ms) | Maximum | 2.16 (1.15, 3.00) | 2.20 (1.15, 3.00) | 2.13 (1.65, 2.93) | 0.938 | 0.938 |
| Minimum | 0.49 (0.01, 1.34) | 0.48 (0.01, 1.34) | 0.54 (0.05, 0.67) | 0.697 | 0.914 | |
| Kurtosis | 0.98 (−1.17, 4.90) | 0.97 (−1.17, 4.90) | 1.07 (−0.30, 4.83) | 0.815 | 0.938 | |
| Skewness | 0.73 (−1.33, 2.05) | 0.78 (−1.33, 2.05) | 0.21 (−0.72, 1.80) | 0.337 | 0.914 | |
| Average | 1.10 (0.56, 2.18) | 1.07 (0.56, 2.18) | 1.14 (1.11, 1.28) | 0.103 | 0.453 | |
| St. Dev. | 0.30 (0.10, 0.61) | 0.30 (0.10, 0.61) | 0.31 (0.14, 0.37) | 0.856 | 0.938 | |
| Dt (μm2/ms) | Maximum | 1.91 (1.12, 2.89) | 1.90 (1.12, 2.89) | 1.96 (1.64, 2.35) | 0.452 | 0.914 |
| Minimum | 0.42 (0.01, 1.37) | 0.4 (0.01, 1.37) | 0.48 (0.05, 0.62) | 0.938 | 0.938 | |
| Kurtosis | 0.76 (−1.08, 4.52) | 0.74 (−1.08, 4.43) | 1.01 (−0.42, 4.52) | 0.736 | 0.914 | |
| Skewness | 0.64 (−1.23, 1.94) | 0.78 (−1.23, 1.94) | 0.27 (−0.61, 1.36) | 0.659 | 0.914 | |
| Average | 1.02 (0.55, 2.16) | 0.99 (0.55, 2.16) | 1.05 (0.96, 1.21) | 0.287 | 0.914 | |
| St. Dev. | 0.26 (0.08, 0.59) | 0.25 (0.08, 0.59) | 0.26 (0.14, 0.35) | 0.938 | 0.938 | |
| fp | Maximum (%) | 29.8 (12.2, 83.1) | 29.6 (12.2, 83.1) | 32.5 (15.9, 69.2) | 0.622 | 0.914 |
| Kurtosis | 0.72 (−0.85, 23.56) | 0.62 (−0.85, 23.56) | 3.37 (−0.85, 5.61) | 0.697 | 0.914 | |
| Skewness | 0.96 (0.04, 4.54) | 0.96 (0.27, 4.54) | 1.73 (0.04, 1.88) | 0.622 | 0.914 | |
| Average (%) | 8.8 (4.8, 19.3) | 8.7 (4.8, 19.3) | 11.7 (5.2, 14.2) | 0.483 | 0.914 | |
| St. Dev. (%) | 5.6 (2.5, 17.0) | 5.2 (2.5, 17.0) | 7.2 (3.2, 11.4) | 0.586 | 0.914 | |
| Dp (μm2/ms) | Maximum | 96.43 (71.36, 99.94) | 96.42 (71.36, 99.8) | 97.42 (80.7, 99.94) | 0.659 | 0.914 |
| Minimum | 0.66 (0.01, 3.07) | 0.80 (0.03, 3.07) | 0.27 (0.01, 2.16) | 0.186 | 0.690 | |
| Kurtosis | 2.37 (−0.15, 17.33) | 1.98 (−0.15, 6.99) | 4.29 (2.73, 17.33) | 0.021 | 0.181 | |
| Skewness | 1.42 (0.52, 2.98) | 1.24 (0.52, 2.31) | 2.04 (1.55, 2.98) | 0.005 | 0.143 | |
| Average | 25.05 (15.99, 37.14) | 25.54 (15.99, 37.14) | 17.16 (16.9, 25.79) | 0.018 | 0.181 | |
| St. Dev. | 17.04 (7.49, 23.44) | 16.82 (14.38, 23.44) | 19.24 (7.49, 19.71) | 0.622 | 0.914 | |
| VTT% | 35.0 (10.3, 72) | 30.0 (10.3, 64.8) | 40.7 (38.4, 72) | 0.052 | 0.335 | |
| Lesion Size (cm2) | 13.84 (3.43, 44.45) | 13.80 (3.43, 37.00) | 23.98 (8.73, 44.45) | 0.248 | 0.607 | |