Differences in association between rural and urban areas, with and without interaction terms. 1a–4a show differences in association between rural and urban areas (from Table 2, models 1d–4d). The lines show modelled association between travel time and alarm symptoms (1a), emergency admission (2a), Dukes’ stage (3a), and 3-year survival (4a). 1b–4b show the difference in the rural versus urban slope, along with 95% CIs. These differences are statistically significant where the CIs do not cross the zero line.