Table 2.
Model | Experimental | |||
---|---|---|---|---|
Day 4 | Day 8 | Day 4 | Day 8 | |
Ablated liver model (Condition A) | ||||
Area of ablated liver (mm3) | 254 | 254 | 155 | 186 |
Ablated liver over [DOX*] (%) | 98.3% | 98.8% | 98.0% | 98.3% |
[DOX] in ablated liver (µg/g)a | 205 [117–430] | 295 [192–398] | 590 [166–1311] | 1008 [361–1796] |
Ablated tumor model (Condition B) | ||||
Area of ablated tumor (mm3) | 254 | 254 | 343 | 418 |
Area of non-ablated tumor (mm3) | 60 | 60 | 195 | 90 |
Non-ablated tumor over [DOX*] (%) | 100% | 61% | 87% | 65% |
[DOX] in non-ablated tumor (µg/g)a | 140 [78–232] | 20 [8–56] | 79 [30–173] | 26 [7–87] |
Values shown are the median concentration. Brackets contain the 25th and 75th percentiles.