Table 2.
Comparison of metabolic features among PCOS, PCOS-with-SCH and controls *
| Variable ** | PCOS TSH <4.2 μUI/ml | PCOS-with-SCH TSH ≥4.2 μUI/ml | Control TSH <4.2 μUI/ml | |||
|---|---|---|---|---|---|---|
| n | Mean±SD | n | Mean±SD | n | Mean±SD | |
| Fasting glucose (mmol/l) | 422 | 5.06±0.61 | 30 | 5.06±0.45 | 195 | 4.70±0.38 a,b |
| Fasting insulin (μmol/l) | 388 | 97.36±63.96 | 23 | 77.75±46.90 | 136 | 52.60±30.00 a |
| Glucose 120 (mmol/l) | 274 | 6.71±2.17 | 17 | 6.09±1.66 | 94 | 5.24±1.43 a,b |
| HbA1C (%) | 305 | 5.76±1.22 | 22 | 5.40±0.99 | 152 | 4.98±0.59 a |
| HOMA-IR | 378 | 1.80±1.15 | 22 | 1.48±0.85 | 129 | 0.96±0.54 a |
| HOMA%B | 379 | 134.35±56.60 | 23 | 152.02±131.01 | 129 | 104.06±38.88 a,b |
| C-peptide (nmol/l) | 277 | 0.81±0.38 | 17 | 0.58±0.27 | 131 | 0.49±0.23 a,c |
| TC (mmol/l) | 380 | 4.80±2.23 | 25 | 4.58±0.92 | 177 | 4.36±1.39 a,b |
| HDL-C (mmol/l) | 371 | 1.17±0.28 | 24 | 1.14±0.27 | 176 | 1.36±0.30 a,b |
| LDL-C (mmol/l) | 369 | 2.86±0.79 | 25 | 2.84±0.78 | 174 | 2.56±0.66 a |
| TG (mmol/l) | 379 | 1.41±0.90 | 25 | 1.47±0.63 | 177 | 1.11±0.79 a |
HbA1C, glycated hemoglobin; HOMA, homeostasis model assessment; TC, total cholesterol; HDL-C, high density lipoprotein - cholesterol; LDL-C, low density lipoprotein-cholesterol; TG, triglyceride
*
One way analysis of variance followed by post hoc Tukey test;
**
PCOS= patients with PCOS and TSH<4.2 μUI/ml.
PCOS-with-SCH = patients with PCOS and TSH >4.2 μUI/ml. Control = normal women with TSH <4.2 μUI/ml
a:
p<0.001 PCOS vs. control;
b:
p<0.001 PCOS-with-SCH vs. control;
c:
p=0.014 PCOS vs. PCOS-with-SCH