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. 2017 Jul 28;49(7):e361. doi: 10.1038/emm.2017.106

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Cells derived from the OPC-like transplants in the injured spinal cord 8 weeks post transplantation. (a) A sagittal section image of the spinal cord illustrating the lesion/transplant site, adjacent area and injury-induced lesion cavity (area within the dotted line) filled with transplants. HNA-positive cells (green) survived and migrated both rostrally and caudally within the injury-induced cavity to distances of at least 5 mm from the transplanted site. Although the majority of HNA-positive cells was located within 1.5–3 mm rostral and caudal to the transplanted site, a larger proportion of cells migrated rostrally. (b) High-magnification images of the small area indicated by the open-headed arrow in a. The survival of oligodendrocytes derived from the transplants was confirmed by triple labeling with DAPI, anti-HNA and anti-MBP antibodies (arrows in photo at the bottom right). (c–e) Coronal section image of the spinal cord, showing other types of surviving cells derived from the transplants (arrows); (c) GFAP-positive cells (red), (d) MAP-positive cells (red) and (e) Ki67-positive cells (red) that are proliferative.