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The PK parameters describing the murine plasma PK of F901318
| Parameter (unit ofmeasure)a |
Mean | Median | SDb | Coefficient of variation (%) |
|---|---|---|---|---|
| SCL (liter/h) | 0.020 | 0.022 | 0.005 | 23.06 |
| Vc (liters) | 0.037 | 0.048 | 0.016 | 43.66 |
| Kcp (h−1) | 17.640 | 22.310 | 6.653 | 37.71 |
| Kpc (h−1) | 15.400 | 21.130 | 8.077 | 52.44 |
SCL is clearance from the central compartment; Vc is the volume of the central compartment; Kcp and Kpc are the respective first-order intercompartmental rate constants.
SD, standard deviation.
