TABLE 2 .
Virulence of S. Typhimurium fimbrial mutants in BALB/c micea
| Strain | Relevant genotype | Oral LD50 (CFU) |
|
|---|---|---|---|
| Expt 1 | Expt 2 | ||
| χ3761 | Wild-type | 3.5 × 102 | NTb |
| χ11467 | Δ(agfC-agfG)-999 ΔsafABCD31 ΔstcABCD36 | 4.2 × 103 | 5.1 × 102 |
| χ11483 | ΔsafABCD31 ΔstiABCH1225 Δ(agfC-agfG)-999 | 1.0 × 103 | 4.1 × 102 |
| χ11505 | ΔsafABCD31 ΔstiABCH1225 ΔstcABCD36 | 5.6 × 102 | 4.0 × 102 |
| χ11507 | Δ(agfC-agfG)-999 ΔstiABCH1225 ΔstcABCD36 | 1.8 × 102 | 1.2 × 103 |
| χ11484 | ΔsafABCD31 ΔstiABCH1225 Δ(agfC-agfG)-999 ΔstcABCD36 | >1.2 × 109 | >2.0 × 109 |
| χ11599 | ΔsafABCD31 ΔstiABCH1225 ΔstcABCD36 Δ(agfC-agfG)-999 | >1.6 × 109 | >1.3 × 109 |
a
BALB/c mice were orally administered graded doses of the indicated strains and monitored for 4 weeks.
b
NT, not tested.