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. 2017 Apr 6;102(7):1173–1184. doi: 10.3324/haematol.2016.162917

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Figure 2. — Drugs identified as hepcidin modulators in Huh7 cells and primary hepatocytes. (A,C,D) Cells were exposed to increasing concentrations of individual drugs for the indicated time points. (B) Effects of 24-hour drug treatments (10 μM imatinib, 50 μM spironolacton) on hepcidin promoter activity in cells transfected with wild-type (WT_2.7) and mutant hepcidin promoter constructs (ST: STAT-BS mutant, B1/B2: double mutant of BMP-RE1 and 2). Results are presented as a fold change (± 95% CI) of hepcidin mRNA levels (A,C,D) or hepcidin promoter activity (Firefly/Renilla luciferase signal) (B) compared to vehicle-treated control cells. The mean of at least three independent experiments is shown. Significant changes are indicated by asterisks: (*P<0.05, **P<0.005, ***P<0.001).