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. 2017 Apr 6;102(7):1173–1184. doi: 10.3324/haematol.2016.162917

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Figure 3. — Refinement of drug target-drug relationships. (A–C) The indicated cell models were exposed to a panel of histone deacetylase (HDAC) inhibitors, SAHA (1 μM), Panobinostat (0.1 μM), Trapoxin A (0.08 μM), Entinostat (1 μM) and Compound-2 (250 nM) for 8 hours (h), in complete medium (A), or in serum-free medium (after a 24-h serum starvation) (B and C). (D) Huh7 cells were treated with increasing concentrations of quercetin for 24 h. (E) Human primary hepatocytes (PH) were exposed to increasing doses of eplerenone for 24 h. All results are presented as a fold change (± 95%CI) of hepcidin mRNA levels. The mean of at least three independent experiments is shown. Significant changes are indicated by asterisks: *P<0.05, **P<0.005, ***P<0.001.