Table 2.

Consensus criteria for organ involvement

Organ	Diagnostic criteria*
Kidney	24-hour urine protein >0.5 g/day, predominantly albumin
Heart	Mean LV wall thickness >12 mm in diastole on echocardiography (no other cardiac cause) Elevated NT-proBNP (>332 ng/L) in the absence of renal failure or atrial fibrillation
Liver	Hepatomegaly with total liver span >15 cm in the absence of heart failure or alkaline phosphatase >1.5 times institutional upper limit of normal
Nerve	Peripheral: symmetric lower extremity sensorimotor peripheral neuropathy Autonomic: gastric emptying disorder, pseudo-obstruction, postural hypotension, erectile dysfunction (males), voiding dysfunction unrelated to direct organ infiltration
Gastrointestinal tract	Direct biopsy verification with symptoms
Lung	Direct biopsy verification with symptoms or Radiographic pattern of interstitial infiltration
Soft tissue	Macroglossia Arthropathy Claudication, presumed vascular amyloid Skin lesions Myopathy by biopsy or pseudohypertrophy of muscle Lymphadenopathy (may be localised) Carpal tunnel syndrome

*Non-invasive diagnostic criteria in patients for whom a diagnosis of systemic amyloidosis has been made by tissue biopsy; once the diagnosis of systemic amyloidosis has been established, biopsy of organs to determine extent of involvement is not recommended.

LV, left ventricular; NT-proBNP, N-terminal fragment of pro-brain natriuretic peptide.