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. 2017 Jul 22;7(12):3021–3033. doi: 10.7150/thno.18992

Figure 5.

Figure 5

GPT2 promotes mammary tumorigenesis A. GPT2 overexpression promotes tumor formation of breast cancer cells. Mice injected with GPT2 overexpressing MDA-MB-231 cells at the indicated cell numbers. The tumors in the blue circles on the left are controls; the tumors in the red circles on the right are overexpression group. B. Depletion of GPT2 reduces tumor formation of breast cancer cells. Mice injected with GPT2 knockdown MCF7 cells at the indicated cell numbers. The tumors in the blue circles on the left are control. C. The expression of GPT2 and ALDH1 was detected by immunofluorescence staining. The data show representative images from three independent experiments. The values on the histogram represent foci numbers per view, 6 views for each group were analyzed. D. Detection of α-KG in xenografted tumors by α-KG assay kit. The data shown is presented as the means ± SD of three independent experiments. E. Expression analysis of GPT2 and HIF1α by Western blot and immunofluorescence staining in cells and in xenografted tumors. The data show representative images from three independent experiments.