Table 2. Risk factors of modification of an antiretroviral regimen containing raltegravir versus dolutegravir within the first year of treatment because of toxicity or intolerance.
Univariate analysis | Multivariate analysis | |||||
Variable | HR | 95% CI | P value | HRa | 95% CI | P value |
Female | 1.86 | 1.39–2.49 | <0.001 | 1.98 | 1.45–2.71 | <0.001 |
Age, per 10 years older | 0.91 | 0.80–1.04 | 0.156 | 0.93 | 0.81–1.07 | 0.319 |
Nonwhite ethnicity | 1.00 | 0.69–1.46 | 0.986 | 0.75 | 0.50–1.13 | 0.172 |
Prior AIDS-defining condition | 0.86 | 0.61–1.22 | 0.405 | 0.89 | 0.56–1.41 | 0.513 |
HCV-coinfection | 0.90 | 0.64–1.26 | 0.538 | 0.80 | 0.56–1.14 | 0.221 |
CD4+ cells per μl | ||||||
<350 | Reference | Reference | ||||
350–500 | 0.89 | 0.58–1.35 | 0.573 | 0.98 | 0.63–1.49 | 0.880 |
>500 | 0.98 | 0.70–1.39 | 0.922 | 1.07 | 0.73–1.56 | 0.735 |
HIV RNA >100 000 copies per ml | 1.45 | 0.87–2.42 | 0.157 | 1.53 | 0.86–2.71 | 0.149 |
Treatment naive | 1.07 | 0.70–1.64 | 0.739 | 1.05 | 0.64–1.70 | 0.858 |
Backbone | ||||||
Abacavir–lamivudine | Reference | Reference | ||||
Tenofovir–emtricitabine | 1.05 | 0.75–1.47 | 0.773 | 0.91 | 0.63–1.32 | 0.626 |
Other | 1.07 | 0.74–1.55 | 0.701 | 0.97 | 0.64–1.49 | 0.902 |
Raltegravir versus dolutegravir | 1.27 | 0.95–1.70 | 0.106 | 1.30 | 0.92–1.84 | 0.140 |
Hazard ratios in univariate and multivariate analysis.
CI, confidence interval; HR, hazard ratio.
aadjusted for all variables listed.