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. 2017 Aug 21;7:8898. doi: 10.1038/s41598-017-09198-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urocortin-1 recovers the hemodynamic function of Langendorff perfused rat hearts submitted to I/R. (A) Graph shows summary data of the contractility expressed as +dP/dt (%) in hearts subjected to ischemia/reperfusion protocol (I/R, full circle, n = 5), and in hearts treated with 10 nM Ucn-1 (+Ucn-1, open square, n = 5). Ucn-1 was applied 5 minutes before ischemia ends and during the first 30 minutes in reperfusion as indicated by area in grey. (B) Shows summary data of the left ventricular end diastolic pressure (LVEDP, mmHg) in the same conditions as in “A”. (C) Bar graph shows the changes in the mean of vascular resistances (VR, mmHg*min/ml). Values were taken 60 minute after reperfusion and were normalized to controls’ values. Data are means ± S.E.M. “*” and “**” indicate significance at p < 0.05 and p < 0.01 of I/R vs +Ucn-1.