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. 2017 Aug 21;7:8898. doi: 10.1038/s41598-017-09198-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Infusion of urocortin-2 improves cardiac function in I/R and regulates the expression of miRNAs. (A) Cardiac function analyzed by echocardiography in M-mode 24 hours after surgery in three experimental models. Images are from “Sham” (n = 5); from “I/R” group corresponding to rats undergoing occlusion of the left coronary artery (LCA) for 40 minutes followed by reperfusion (n = 6); and for I/R rats infused with Ucn-2 (150 µg/Kg) 5 minutes before reperfusion (n = 5). (B,C) Bar graphs summarize ejection fraction (EF, %) and shortening fraction (SF, %) measured in rats infused with 50, 150 or 300 µg/Kg of Ucn-2. (D–F) Bar graphs showing the expression of miR-125a-3p, miR-324-3p and miR-139-3p, respectively in hearts from Sham, I/R animal model, and from I/R rats infused with Ucn-2 (150 µg/Kg; +Ucn-2). Values are shown in logarithmic scale. Data show means ± S.E.M. (n = 5–7). “*” and “**” indicate significance at p < 0.05 and p < 0.01, respectively.