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. 2017 Aug 21;7:8898. doi: 10.1038/s41598-017-09198-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urocortin-1 regulates the expression of BRCA1, STAT2, BIM, FoxO1 and MAP3K12 in isolated cardiac myocytes under I/R. Bar graphs show rate changes of genes’ mRNA expression assessed by qRT-PCR in adult rat cardiac myocytes (control); in untreated cells undergoing I/R protocols myocytes (I/R); and in cells treated with Ucn-1 in I/R (10 nM, +Ucn1). Values are in logarithmic scale normalized to control and are means ± S.E.M (n = 8). “*” and “**” indicate significance at p < 0.05 and p < 0.01, respectively. “&” indicates significance between I/R and control at p < 0.05.