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. 2017 Apr 19;4(8):1600493. doi: 10.1002/advs.201600493

Figure 5.

Figure 5

Downregulation of excitatory receptor and postsynaptic transmission after BPA exposure. A,B) Representative immunoblot and corresponding densitometric analysis showing the ratios of expression amounts of NMDA receptor subtypes (NR1, NR2A, and NR2B to GAPDH (#p > 0.05, *p < 0.05, and #p > 0.05, respectively) and AMPA receptor subtypes (GluR1 and GluR2) to GAPDH in control and juvenile BPA treated groups (n = 8 rats per group, *p < 0.05 and p > 0.05, respectively); C,D) Excitatory synaptic transmission in BPA‐treated brain slices (10 × 10−6 m) was assessed by recording NMDA and AMPA receptor mediated current in the hippocampal CA1 areas, as shown by decreased EPSCNMDA, not EPSCAMPA, after acute BPA treatment (n = 8 rats per group, *p < 0.05 and p > 0.05, respectively).