Table 3.

Cause-specific HRs from a multivariate proportional hazards model for first-appearing IAA only and GADA only and multiple IA at seroconversion by age 6 years

Factor	Comparison	IAA only		GADA only		Multiple IA
		HR	P	HR	P	HR	P
Sex	Male vs. female	1.36	0.02	1.25	0.11	1.15	0.51
Family history	FDR mother vs. GP	0.87	0.66	1.56	0.15	1.42	0.32
	FDR father vs. GP	2.33	<0.0001	2.49	<0.0001	2.16	0.02
	FDR sibling vs. GP	5.32	<0.0001	1.60	0.33	2.73	0.05
HLA	DR3/4 vs. DR4/4,X	1.18*	0.23	1.92*	0.0001	1.52	0.06
	DR3/3,X vs. DR4/4,X	0.27*	<0.0001	1.60*	0.02	0.23	0.005
Country	Finland vs. U.S.	1.93*	0.0003	0.73*	0.14	1.31	0.37
	Germany vs. U.S.	1.70*	0.05	0.53*	0.09	2.59	0.008
	Sweden vs. U.S.	1.32	0.12	0.91	0.57	1.03	0.91
Probiotics at age 28 days	Yes vs. no or ≥28 days	0.54	0.03	0.64	0.21	0.89	0.75
Weight at age 12 months	z score	1.16	0.02	1.29	0.0003	1.13	0.26
Child conditions before first clinical visit (age 3 months)	Upper resp. (yes vs. no)	1.23	0.18	0.94	0.70	1.25	0.36
	Lower resp. (yes vs. no)	0.97	0.87	1.10	0.64	0.44	0.07
	Diarrhea (yes vs. no)	1.36	0.16	0.94	0.82	1.20	0.60
	Rash (yes vs. no)	1.01	0.94	0.83	0.31	1.10	0.71
rs689 (INS)	Yes vs. no	0.47*	<0.0001	1.06*	0.68	0.56	0.01
rs231775 (CTLA4)	Yes vs. no	0.88*	0.38	1.33*	0.07	1.00	0.99
rs2476601 (PTPN22)	Yes vs. no	1.77	<0.0001	1.63	0.002	1.70	0.02
rs2816316 (RGS1)	Yes vs. no	0.97	0.83	0.99	0.92	1.40	0.12
rs10517086	Yes vs. no	1.05	0.70	0.98	0.88	1.31	0.21
rs4948088 (COBL)	Yes vs. no	0.56	0.05	0.86	0.56	0.61	0.29
rs2292239 (ERBB3)	Yes vs. no	1.42	0.01	1.60	0.002	1.30	0.23
rs3184504 (SH2B3)	Yes vs. no	1.25	0.15	1.76	0.001	1.12	0.64
rs12708716 (CLEC16A)	Yes vs. no	0.96	0.78	0.76	0.06	0.67	0.06
rs3757247 (BACH2)	Yes vs. no	0.78*	0.07	1.49*	0.01	1.10	0.68

Data set in boldface indicate statistical significance. Lower resp., lower-respiratory infection; Upper resp., upper-respiratory infection.

*IAA only–to–GADA only ratio significantly changed (P < 0.05) by factor as determined in multivariate logistic regression.