Table 1.
Met Case Criteria (n = 102) | Did Not Meet Case Criteria (n = 70) | |
---|---|---|
Female sex | 70 (68.6) | 36 (51.4) |
Age at isolation, yr, median (range) | 67 (12–92) | 67 (26–93) |
Species | ||
Mycobacterium avium complex | 91 (89.2) | 52 (74.3) |
Mycobacterium abscessus/chelonae complex | 6 (5.9) | 2 (2.9) |
Mycobacterium fortuitum complex | 0 (0) | 4 (5.7) |
Other (includes unspeciated) | 5 (4.9) | 12 (17.1) |
Cavitation | 26 (25.5) | 5 (7.1) |
Nodular/interstitial infiltrate | 90 (88.2) | 40 (57.1) |
Bronchiectasis diagnosis by physician or findings on based on CT | 43 (42.2) | 16 (22.9) |
Bronchiectasis findings based on CT only* | 36 (35.3) | 10 (14.3) |
COPD | 29 (28.4) | 23 (32.9) |
Lung cancer | 2 (2) | 4 (5.7) |
Prior tuberculosis | 9 (8.8) | 3 (4.3) |
Prior NTM isolation† | 8 (7.8) | 1 (1.4) |
Cystic fibrosis | 2 (2) | 1 (1.4) |
Other lung disease‡ | 6 (5.9) | 4 (5.7) |
Nonsteroid immunosuppressive medication§ | 10 (9.8) | 4 (5.7) |
Any steroid use | 22 (21.6) | 21 (30.0) |
Oral prednisone | 17 (16.7) | 14 (20) |
Inhaled corticosteroid with or without LABA | 7 (6.9) | 9 (12.9) |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; CT = computed tomography; LABA = long-acting β-agonist; NTM = nontuberculous mycobacteria.
Numbers are count (percent) except as noted. Boldface type indicates P < 0.05. Comparison is of patients meeting American Thoracic Society/Infectious Diseases Society of America pulmonary disease case criteria (4) at baseline with those who did not.
Ninety cases had CT scan (40% had bronchiectasis); 44 noncases had CT scan (22.7% had bronchiectasis, P = 0.05 for comparison)
History of NTM isolation prior to baseline period.
Other lung disease includes interstitial lung disease, sarcoidosis, or allergic bronchopulmonary aspergillosis.
Nonsteroid immunosuppressive medications include methotrexate, tacrolimus, cyclosporine, biologics, and azathioprine.