Table 3.

Sleep parameters

	Placebo	4-AP	P value
TST, min	311.5 [65.8]	282.5 [55.0]	0.32
SE, %	84.9 [16.4]	79.3 [18.8]	0.38
NREM1, %TST	10.5 [5.9]	10.3 [13.5]	0.27
NREM2, %TST	50.3 [12.0]	54.7 [8.8]	0.32
NREM3, %TST	21.4 [8.1]	15.1 [5.8]	0.23
REM, %TST	16.7 [5.9]	12.1 [12.0]	0.13
AHI, events/hour	0.0 [0; 0]	0.0 [0; 0]	>0.5
ArI, events/hour	10.3 [6.8]	6.3 [7.5]	>0.5

Definition of abbreviations: 4-AP = 4-aminopyridine; AHI = apnea-hypopnea index; ArI = arousal index; NREM1, NREM2, and NREM3 = non-rapid eye movement sleep stages 1, 2, and 3; REM = rapid eye movement sleep; SE = sleep efficiency; TST = total sleep time.

Data are expressed as median [interquartile range].