Table 1.
Probability of IRG DEG enrichment in CNS and CD4 T lymphocytes during experimental neuroinflammation.
| IRG DEG | All IRG | IRG DEG % | Global DEG | Expressed Global genes | Global DEG % | Chi square (Yate’s correction) | P-value | Z-score | |
|---|---|---|---|---|---|---|---|---|---|
| D20_Sc | 575 | 4022 | 14.29 | 1052 | 16589 | 6.34 | 563.9 | 0.00001 | 23.7 |
| D40_Sc | 858 | 4022 | 21.33 | 2983 | 16589 | 17.98 | 40.12 | 0.00001 | 6.35 |
| Th17iv | 1926 | 4147 | 46.44 | 7704 | 19149 | 40.2 | 84.60 | 0.00001 | 9.21 |
| Th17eae | 2614 | 4147 | 63.03 | 10556 | 19014 | 55.5 | 120.9 | 0.00001 | 11.01 |
| CD4eae | 2725 | 4147 | 65.71 | 11698 | 18978 | 61.6 | 36.96 | 0.00001 | 6.09 |
DEG = differentially expressed gene; Sc = Spinal cord; eae = experimental autoimmune encephalomyelitis; Th17iv = in vitro differentiated T helper 17 cells.