Figure 4.

Pathway flux and model agreement with expression data. The degree of agreement between the model-based flux predictions and expression data for each of the three metabolic models is shown, both for the entire models and broken down by categories of metabolism. In the graph, reactions are divided into five categories based on their flux and the expression of their associated genes: (i) reactions that are active and associated with at least one expressed gene (dark blue); (ii) reactions that are inactive and associated only with unexpressed genes (dark red); (iii) reactions that are inactive and associated with one or more expressed genes (green); (iv) reactions that are active and associated only with unexpressed genes (purple); and (v) gapfilled reactions associated with no genes. The dark blue and dark red categories indicate agreement between the models and expression data; purple and green categories indicate disagreement.