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. 2017 Aug 21;7:8906. doi: 10.1038/s41598-017-08360-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure of human IL-17A/F. (a) Ribbon diagram of IL-17A/F (center view; A chain, carmine; F chain, orange) and comparison with IL-17A (left, 4hr9.pdb) and IL-17F (right, 1jpy.pdb). Disulfides are represented with spheres. Sugar residues are shown in stick representation. Observed N- and C-termini of IL-17A/F are boxed. The tip of the second β-hairpin of the F-chain is highlighted with a dotted ellipse. (b) Upside down orientation emphasizing the analogy between the IL-17 fold and a garment. Structurally-conserved regions in IL-17A/F with respect to the corresponding homodimers are in grey, while non-conserved structural elements are in carmine (A chain) or orange (F chain). The β-strands forming the two β-hairpins of each subunit are numbered sequentially 1 to 4.