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. 2017 Aug 16;11:2377–2386. doi: 10.2147/DDDT.S143749

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© 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited

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The effects of ICV injection of O-n-octanoylated ghrelin and α-MSH (1.0 or 2.0 nmol/rat) on cumulative food intake in freely fed rats. After ICV injection of saline (vehicle) or α-MSH, O-n-octanoylated ghrelin was injected ICV immediately, and cumulative food intake was measured at 1, 2, 4, 8, 12, and 24 h.

Notes: The results are shown in (A–F), respectively. Data are presented as mean ± SEM; *P<0.05, **P<0.01, ***P<0.001, compared to the vehicle-injected group; ^#P<0.05, ##P<0.01, ^###P<0.001, compared to the O-n-octanoylated ghrelin-injected control group. n=12 rats in each group.

Abbreviations: α-MSH, α-melanocyte stimulating hormone; ICV, intracerebroventricular; SEM, standard error of the mean.