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. 2017 Aug 16;11:2377–2386. doi: 10.2147/DDDT.S143749

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© 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited

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The effects of ICV injection of O-n-octanoylated ghrelin and α-MSH (1.0 or 2.0 nmol/rat) on 30 min charcoal, non-nutrient, semi-liquid gastric emptying rate in conscious rats deprived of food for 16 h.

Notes: After ICV injection of saline (vehicle) or α-MSH (1.0 or 2.0 nmol/rat), O-n-octanoylated ghrelin was ICV injected immediately. O-n-octanoylated ghrelin (0.1 nmol/rat) significantly enhanced gastric emptying. α-MSH (1.0 or 2.0 nmol/rat) had no effect of attenuating on the enhancement of gastric emptying induced by O-n-octanoylated ghrelin. Data are presented as mean ± SEM. ***P<0.001, compared to the vehicle-injected group. n=8 rats in each group.

Abbreviations: α-MSH, α-melanocyte stimulating hormone; ICV, intracerebroven-tricular; SEM, standard error of the mean.