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. 2017 Aug 16;11:2377–2386. doi: 10.2147/DDDT.S143749

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© 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited

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The effects of ICV injection of O-n-octanoylated ghrelin and α-MSH (1.0 or 2.0 nmol/rat) on the geometric center and the running percentage of small intestinal transit in 16 h food-deprived conscious rats.

Notes: ICV injection of O-n-octanoylated ghrelin significantly increased the geometric center of small intestinal transit, and 2 nmol/rat α-MSH significantly attenuated this stimulation (A). Note that the accelerated effect on the running percentage of small intestinal transit induced by ICV injection of O-n-octanoylated ghrelin was not attenuated by ICV α-MSH (B). Data are presented as mean ± SEM. ***P<0.001, compared to the vehicle-injected group; ^##P<0.01, compared to the O-n-octanoylated ghrelin-injected control group. n=8 rats in each group.

Abbreviations: α-MSH, α-melanocyte stimulating hormone; ICV, intracerebroventricular; SEM, standard error of the mean.