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. 2017 Aug 21;7:8953. doi: 10.1038/s41598-017-09518-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacokinetic profile of TRAIL-Trimer and native TRAIL determined by western blot. Mice were injected intravenously with equimolar amounts of TRAIL-Trimer (40 mg/kg) or native TRAIL (15 mg/kg) (n = 3 for each protein). (a,c) Relative serum concentrations of both TRAIL-Trimer (a) and native TRAIL (c) were evaluated at periodic intervals by western blotting. TRAIL proteins were immunoblotted with an antibody against human TRAIL, and visualized by chemiluminescence. The images were acquired using the ChemiDoc Touch Imaging System (Bio-Rad) and the quantification of the amount of TRAIL proteins present in each sample was done using Image Lab software (Bio-Rad). (b,d) Estimated half-lives of TRAIL-Trimer (b) and native TRAIL (d) were calculated using GraphPad Prism v5.04. Error bars represent ± SEM.