Table 2.

Concentrations of bile acids in sera and liver after rats treated with Geniposide for 3 days.

	control	Geniposide
	—	100 mg/kg	300 mg/kg
Sera (μg/ml)
T-α-MCA	0.0627 ± 0.0551	0.0413 ± 0.0294	0.145 ± 0.0772*
THDCA	0.183 ± 0.203	0.138 ± 0.0539	0.126 ± 0.0355
TCA	0.138 ± 0.133	0.123 ± 0.0937	0.712 ± 0.571*
TCDCA	0.0448 ± 0.0259	0.0669 ± 0.0152*	0.124 ± 0.0260***
TDCA	0.0525 ± 0.0433	0.0387 ± 0.0295	0.109 ± 0.0987
GUDCA	0.0611 ± 0.00289	0.0612 ± 0.00328	0.0615 ± 0.00155
GHDCA	0.445 ± 0.633	0.186 ± 0.232	0.0735 ± 0.0558
GCDCA	0.0597 ± 0.0648	0.0380 ± 0.0453	0.0405 ± 0.0292
GDCA	0.119 ± 0.137	0.0861 ± 0.140	0.0750 ± 0.0595
GCA	0.988 ± 1.078	1.557 ± 1.655	1.871 ± 1.147
β-MCA	0.460 ± 0.434	0.788 ± 0.486	1.128 ± 0.330**
CA	0.555 ± 0.781	0.886 ± 0.744	1.477 ± 1.256
UDCA	0.0817 ± 0.0547	0.0447 ± 0.0249	0.0576 ± 0.0255
HDCA	1.492 ± 1.066	0.619 ± 0.182*	0.427 ± 0.123*
CDCA	0.0903 ± 0.147	0.105 ± 0.0939	0.135 ± 0.142
DCA	0.137 ± 0.0630	0.146 ± 0.109	0.165 ± 0.103
Liver (μg/g)
T-α-MCA	36.112 ± 15.073	36.983 ± 16.058	61.974 ± 14.241**
THDCA	20.798 ± 10.187	11.927 ± 4.966*	7.730 ± 2.746**
TCA	47.005 ± 21.610	65.257 ± 24.042	126.849 ± 32.844***
TCDCA	4.269 ± 2.075	3.785 ± 1.578	11.199 ± 6.825*
TDCA	12.250 ± 8.509	8.903 ± 3.776	11.964 ± 8.065
GUDCA	0.173 ± 0.189	0.136 ± 0.152	0.139 ± 0.133
GHDCA	2.955 ± 3.941	1.190 ± 1.466	0.395 ± 0.523
GCA	12.660 ± 11.362	17.873 ± 16.076	21.914 ± 16.195
GCDCA	0.393 ± 0.499	0.291 ± 0.402	0.349 ± 0.301
GDCA	1.754 ± 1.608	0.949 ± 0.995	0.755 ± 0.732
β-MCA	0.413 ± 0.495	0.288 ± 0.235	0.595 ± 0.376
CA	0.145 ± 0.167	0.0876 ± 0.0864	0.779 ± 1.624
HDCA	0.470 ± 0.420	0.0817 ± 0.0324*	0.0804 ± 0.0346*
CDCA	0.0437 ± 0.0270	0.0363 ± 0.0120	0.0429 ± 0.0259

Data are presented as means ± SD concentrations in sera and liver measured using UPLC-MS/MS of 7–8 rats. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group of same bile acid.