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. 2017 Aug 21;3:30. doi: 10.1038/s41523-017-0036-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The SERM-dependent, SNP-dependent “reversal” of estradiol induction of ZNF423 and BRCA1 expression in LCLs. a Estradiol (E2) and 4-hydroxytamoxifen (4OH-TAM) dose response curves for expression of ZNF423 (a) and BRCA1 (b) in LCLs with known genotypes for the ZNF423 intron 2 rs9940645 SNP. Values are mean ± SEM for 8 determinations. (modified from Fig. 3, Ingle et al. Cancer Discovery 2013⁶)