Table 1.
SNPs across the ZNF423 gene on chromosome 16 and SNPs across the CTSO gene on chromosome 4 within ±500 bp of ERE motifs with p values ≤ 10E-03. p values are for associations with the occurrence of breast cancer during SERM therapy
| SNP rs ID | SNP Position on Chr.16 | Motif Sequence | Motif Start Position | Motif End Position | Strand | Distance from Motif | MAF (400) | MAF (all samples) | Common.Variant | p Value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs7187662 | 49614038 | GTTGGTCTGGATGACTC | 49613770 | 49613787 | − | 250 | 0.20125 | 0.219389 | T | 6.11E-04 |
| rs72780324 | 49691162 | CATGGATTCCCTGACCT | 49690861 | 49690878 | + | 283 | 0.05250 | 0.049403 | A | 7.03E-04 |
| rs746157 | 49593393 | GAAGGGGCAGCTGACTC | 49592974 | 49592991 | − | 401 | 0.17250 | 0.190402 | T | 8.44E-04 |
| rs12925456 | 49596645 | GATGGTCTTGATCTCCT | 49596906 | 49596923 | + | 261 | 0.17125 | 0.189488 | T | 1.17E-03 |
| rs11642983 | 49597423 | GATGGTCTTGATCTCCT | 49596906 | 49596923 | + | 499 | 0.17125 | 0.189488 | T | 1.17E-03 |
| rs72780328 | 49708387 | CAGAGCCACCCTGTCCT | 49708366 | 49708383 | − | 3 | 0.03625 | 0.035656 | C | 1.98E-03 |
| rs71382759 | 49600680 | GATGAGCTAGCTCACCC | 49601144 | 49601161 | + | 464 | 0.09375 | 0.115006 | C | 3.04E-03 |
| rs12918288 | 49593188 | GAAGGGGCAGCTGACTC | 49592974 | 49592991 | − | 196 | 0.09625 | 0.116332 | G | 3.43E-03 |
| rs57148286 | 49688324 | CAGGGACAGCATGAGCT | 49688371 | 49688388 | − | 47 | 0.05875 | 0.063394 | G | 6.23E-03 |
| SNP rs ID | SNP Position on Chr.4 | Motif Sequence | Motif Start Position | Motif End Position | Strand | Distance from Motif | MAF (400) | MAF (all samples) | Common.Variant | p Value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1490555 | 157251916 | CTGTTTCAGCTTGACTT | 157251780 | 157251797 | + | 118 | 0.18125 | 0.175165 | T | 3.83E-03 |
| rs1490556 | 157251977 | CTGTTTCAGCTTGACTT | 157251780 | 157251797 | + | 179 | 0.18125 | 0.175165 | A | 3.83E-03 |
| rs1873358 | 157252132 | CTGTTTCAGCTTGACTT | 157251780 | 157251797 | + | 334 | 0.18125 | 0.175165 | A | 3.83E-03 |
| rs2879978 | 157252282 | CTGTTTCAGCTTGACTT | 157251780 | 157251797 | + | 484 | 0.18125 | 0.175165 | G | 3.83E-03 |
| rs10010729 | 157248748 | GAAGGGTAAGAGGAACT | 157248919 | 157248936 | − | 171 | 0.16875 | 0.165087 | G | 5.09E-03 |
| rs1490554 | 157251896 | CTGTTTCAGCTTGACTT | 157251780 | 157251797 | + | 98 | 0.16875 | 0.165087 | A | 5.09E-03 |
| rs2101586 | 157261188 | CTGGGTTTACATGACCT | 157261391 | 157261408 | + | 203 | 0.16875 | 0.165087 | C | 5.09E-03 |
| rs6536168 | 157261438 | CTGGGTTTACATGACCT | 157261391 | 157261408 | + | 29 | 0.16875 | 0.165087 | C | 5.09E-03 |
| rs4691210 | 156919006 | TTAGGGTAGAATGACTC | 156918505 | 156918522 | + | 483 | 0.02125 | 0.034025 | T | 7.99E-03 |
| rs4691214 | 156923110 | CAAAGCCAGCTGGACTT | 156923087 | 156923104 | + | 5 | 0.02125 | 0.034025 | A | 7.99E-03 |
| rs4691216 | 156923435 | CATGGTCTCGCTGACTT | 156923576 | 156923593 | − | 141 | 0.02125 | 0.034025 | C | 7.99E-03 |
| rs4234895 | 156923944 | CATGGTCTCGCTGACTT | 156923576 | 156923593 | − | 350 | 0.02125 | 0.034025 | T | 7.99E-03 |