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. 2017 Aug 21;7:9007. doi: 10.1038/s41598-017-08444-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Light microscopy of subcutaneous adipose tissue (SAT) of an obese patient with type 2 diabetes. Immunohistochemistry for CD68. (A) Cyst-Like-Structure (Cys-LS) formed by CD68 immunoreactive macrophages and multinucleated giant cells (MGC) surrounding fat, amidst hypertrophic adipocytes. Note the giant size of Cys-LS in comparison with hypertrophic adipocytes and the largest CLS found in the same patient. (B) Magnification of the inset in A.