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. 2017 Aug 21;7:8412. doi: 10.1038/s41598-017-08688-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neuroserpin was immunoprecipitated from (A) human retinal (B) vitreous and (C) ONH tissue lysates using anti-neuroserpin antibody and subjected to gelatin zymography to evaluate the plasmin inhibitory activity of the neuroserpin (n = 6 each). (D) Immunoprecipitated neuroserpin from control and high IOP rat retinas were subjected to gelatin gel zymography to assess its plasmin inhibitory activity (n = 5). Immunoprecipitates were also loaded for western blotting and developed for neuroserpin immunoreactivity in each case. Blots were cropped to show the relevant band. Relative band intensities were quantified and data analysis indicated significantly decreased plasmin inhibitory activity in human vitreous and ONH glaucoma samples and high IOP induced rat retinas compared to the respective controls (*p < 0.05; **p < 0.01).