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. 2017 Aug 21;7:8950. doi: 10.1038/s41598-017-09511-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in hippocampal sharp-wave ripple (SWR) activity before and after Clozapine N-oxide (CNO) Administration in mice with bilateral injections of DREADD vector in OB. (a) Average LFP waveform aligned on the SWR onset (t = 0). Solid blue and red lines represents mean LFP traces pre- and post-CNO treatment, respectively. Shading represents standard error. (b) Comparison of normalized spectral power within the 100–200 Hz frequency band pre- and post-CNO treatment. Two-Sample t-test: *p < 0.05. (c) Polar coordinates (°) for SWR activities during respiratory cycles, showing normalized vectors (thicker line areas) and mean vector length (red arrow; r) determined by circular statistics (Rayleigh test). 0° represents the end of expiration. The largest circle represents the maximum r (1.0). Pre-CNO: r = 0.18; z = 9.73; p < 0.001; Post-CNO: r = 0.09; z = 2.53; p = 0.278.