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. 2017 Aug 21;7:8907. doi: 10.1038/s41598-017-09331-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CXCR5⁺ and CXCR5⁻ CD4 T cell response to YF virus C, prM and E peptides. (a) CD4⁺ CD45Ra⁻ memory T cells from PBMC of healthy donors were sorted into CXCR5⁺ (upper right) and CXCR5⁻ cells (lower left). (b) IgG concentration revealed by ELISA in supernatants of sorted autologous B cells cultured for 10 days with either CXCR5⁺ or CXCR5⁻ cells in 4 independent experiments. Statistical signifiance was determined with the two-way ANOVA. (c) Percentage of cytokine events in sorted CXCR5⁺ and CXCR5⁻ subsets contributed by C, prM and E peptides as determined by intracellular cytokine staining. (d) Ratios of results with E and C peptides obtained in individual donors. Statistical signifiance was determined with the Wilcoxon matched-pairs signed rank test.