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. 2017 Aug 21;7:8893. doi: 10.1038/s41598-017-08086-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trypanosoma cruzi strains differently impact organs during acute and chronic infection. (A) Damage to intestine and heart vary among strains and phases. Damage was assessed upon dissection by macroscopic observation and resistance to pressure and extension, resulting in a 3-grade scale: 0, unaffected (white), 1, low damage (gray), 2, high damage (black). Each animal is represented by a coloured square. Hepatosplenomegaly is a common feature of both acute and chronic phases, with sensible differences among strains. (B,C) Mass index is the weight of infected animals normalized to controls, grouped per strain and per phase (coloured bars), and according to organ damage (white, gray, and black bars) for liver (B) and spleen (C). Dotted lines stand for the mean of all infected animals. Data are the mean per group ± S.E.M.