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. 2017 Aug 21;7:8979. doi: 10.1038/s41598-017-08150-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Heatmap and (B) Clustering dendrogram (Bray-Curtis and Ward linkage) for genus-level OTU data. Figure A. demonstrates that three clusters of mucosal bacteria predmoninate and that on and off cancer samples appear to cluster together. In (B) the grey boxes highlight samples taken from tumour, 5 cm off tumour and 10 cm off tumour from the same individuals which cluster together. This shows that 8 out of 18 patients demonstrated significant homogeneity in mucosal bacteria on cancer and at 5 and 10 cms. This clustering effect is greater than any clustering associated with sampling location, suggesting that individual variation is a greater influence on CRC microbiome dysbiosis than colonic geographical sampling site relative to the tumour.