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. 2017 Aug 21;7:8979. doi: 10.1038/s41598-017-08150-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High Resolution – Magic Angle Spinning (HR-MAS) Nuclear Magnetic Resonance (NMR) analysis of mucosal metabolism using orthogonal partial least squares discriminant analysis. (a) Cross validated scores plot using Maximum Margin Criteria, and a leave one patient out validation. (b) The corresponding ROC curve demonstrating the diagnostic accuracy of the model (AUC 0.96). (c) Pseudo-loadings ANOVA plot of the MMC cross validated model, demonstrating co-variance of metabolites between on and off cancer sampling points. The colour code provides a visual description of FDR p values for each signal. Peaks point in the direction of the tissue state with which they are positively associated (up or down) and signals red in colour have greater statistical significance.