Table 4.
Hazard ratio of mortality in univariate and multivariate Cox regression analysis
| Univariate
|
Multivariate (enter method)
|
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Baseline serum HS-CRP (mg/L) | 1.018 | 1.007–1.028 | 0.001 | 0.984 | 0.961–1.008 | 0.187 |
| Time-averaged serum HS-CRP (mg/L) | 1.037 | 1.025–1.050 | <0.001 | 1.028 | 1.001–1.056 | 0.044 |
| Male | 1.005 | 0.563–1.795 | 0.986 | |||
| Age (years) | 1.083 | 1.059–1.108 | <0.001 | 1.066 | 1.036–1.096 | <0.001 |
| Body mass index (kg/m2) | 1.058 | 0.986–1.135 | 0.116 | |||
| DM | 4.182 | 2.373–7.370 | <0.001 | 1.477 | 0.614–3.554 | 0.384 |
| CAD | 4.266 | 1.535–11.853 | 0.005 | 1.456 | 0.418–5.073 | 0.555 |
| CHF | 0.671 | 0.163–2.758 | 0.580 | |||
| Stroke | 3.120 | 1.407–6.923 | 0.005 | 1.397 | 0.536–3.641 | 0.494 |
| SLE | 0.460 | 0.064–3.327 | 0.442 | |||
| Liver cirrhosis | 1.885 | 0.749–4.744 | 0.178 | |||
| Hepatitis B | 0.888 | 0.379–2.079 | 0.784 | |||
| Hepatitis C | 1.627 | 0.647–4.093 | 0.301 | |||
| PD duration (months) | 0.997 | 0.990–1.005 | 0.494 | |||
| Residual urine | 0.544 | 0.313–0.945 | 0.031 | 0.730 | 0.389–1.373 | 0.329 |
| White blood cell count (1,000/µL) | 1.054 | 0.963–1.154 | 0.250 | |||
| Hemoglobin (g/dL) | 0.853 | 0.716–1.017 | 0.077 | |||
| Platelet count (1,000/µL) | 0.998 | 0.995–1.002 | 0.416 | |||
| Albumin (g/dL) | 0.397 | 0.227–0.691 | 0.001 | 0.575 | 0.231–1.432 | 0.235 |
| Total cholesterol (mg/dL) | 0.998 | 0.993–1.004 | 0.527 | |||
| HDL (mg/dL) | 0.991 | 0.971–1.012 | 0.399 | |||
| LDL (mg/dL) | 0.996 | 0.988–1.003 | 0.277 | |||
| Triglyceride (mg/dL) | 1.001 | 0.999–1.003 | 0.391 | |||
| HbA1c (%) | 1.456 | 1.209–1.753 | <0.001 | 1.028 | 0.694–1.523 | 0.889 |
| Blood urine nitrogen (mg/dL) | 0.998 | 0.983–1.014 | 0.842 | |||
| Creatinine (mg/dL) | 0.905 | 0.820–0.999 | 0.048 | 1.119 | 0.987–1.268 | 0.080 |
| Uric acid (mg/dL) | 1.085 | 0.874–1.346 | 0.462 | |||
| Calcium (mg/dL) | 0.845 | 0.650–1.099 | 0.208 | |||
| Phosphorus (mg/dL) | 0.906 | 0.732–1.120 | 0.360 | |||
| Aluminum (µg/dL) | 0.921 | 0.643–1.319 | 0.653 | |||
| iPTH (pg/mL) | 1.000 | 0.999–1.000 | 0.403 | |||
| Transferrin saturation (%) | 0.033 | 0.002–0.589 | 0.020 | 0.083 | 0.004–1.948 | 0.122 |
| Ferritin (µg/L) | 1.000 | 1.000–1.001 | 0.350 | |||
| PD system (Fresenius Stay Safe) | 0.902 | 0.125–6.529 | 0.919 | |||
| PD modality (APD) | 1.439 | 0.754–2.743 | 0.270 | |||
| Daily dwell volume (L) | 1.003 | 0.873–1.153 | 0.961 | |||
| Icodextrin | 0.625 | 0.360–1.083 | 0.094 | |||
| Nutrineal | 1.589 | 0.826–2.973 | 0.323 | |||
| Dialysate dextrose (%) | 1.235 | 0.724–2.104 | 0.439 | |||
| Dialysate calcium (2.5 mEq/L) | 1.114 | 0.677–1.833 | 0.671 | |||
| Dialysate/plasma creatinine | 13.239 | 1.386–126.46 | 0.025 | 2.703 | 0.175–41.773 | 0.477 |
| Weekly Kt/V urea (total) | 0.442 | 0.200–1.003 | 0.053 | |||
| Weekly CCr (normalized) | 0.977 | 0.956–1.012 | 0.062 | |||
| Cardiovascular event(s) | 4.792 | 2.750–8.350 | ,0.001 | 2.092 | 1.086–4.028 | 0.027 |
| Infection episode(s) | 2.093 | 1.097–3.993 | 0.025 | 1.110 | 0.558–2.206 | 0.766 |
| Malignancy | 1.610 | 0.758–3.421 | 0.215 | |||
| EPS | 0.046 | 0.000–14.748 | 0.296 | |||
Abbreviations: HR, hazard ratio; CI, confidence interval; HS-CRP, high-sensitivity C-reactive protein; DM, diabetes mellitus; CAD, coronary artery disease; CHF, congestive heart failure; SLE, systemic lupus erythematosus; PD, peritoneal dialysis; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycated hemoglobin; iPTH, intact parathyroid hormone; APD, automated peritoneal dialysis; CCr, creatinine clearance; EPS, encapsulating peritoneal sclerosis.