Table 5.
Hazard ratio of dropout (transplantation censored) in univariate and multivariate Cox regression analysis
| Univariate
|
Multivariate (enter method)
|
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Baseline serum HS-CRP (mg/L) | 1.008 | 1.001–1.017 | 0.048 | 0.985 | 0.968–1.003 | 0.106 |
| Time-averaged serum HS-CRP (mg/L) | 1.024 | 1.015–1.034 | <0.001 | 1.024 | 1.005–1.044 | 0.015 |
| Male | 1.060 | 0.756–1.487 | 0.735 | |||
| Age (years) | 1.028 | 1.014–1.041 | <0.001 | 1.012 | 0.995–1.029 | 0.156 |
| Body mass index (kg/m2) | 0.989 | 0.946–1.035 | 0.642 | |||
| DM | 1.895 | 1.282–2.802 | 0.001 | 1.189 | 0.635–2.224 | 0.588 |
| CAD | 2.478 | 1.159–5.295 | 0.019 | 1.463 | 0.601–3.564 | 0.402 |
| CHF | 1.202 | 0.633–2.282 | 0.575 | |||
| Stroke | 1.703 | 0.944–3.073 | 0.077 | |||
| SLE | 0.500 | 0.159–1.568 | 0.235 | |||
| Liver cirrhosis | 1.535 | 0.851–2.771 | 0.155 | |||
| Hepatitis B | 1.198 | 0.768–1.867 | 0.425 | |||
| Hepatitis C | 1.411 | 0.799–2.492 | 0.235 | |||
| PD duration (months) | 1.006 | 1.003–1.010 | <0.001 | 1.000 | 0.994–1.006 | 0.919 |
| Residual urine | 0.639 | 0.461–0.886 | 0.007 | 0.997 | 0.613–1.621 | 0.990 |
| White blood cell count (1,000/µL) | 1.032 | 0.977–1.091 | 0.259 | |||
| Hemoglobin (g/dL) | 0.871 | 0.785–0.966 | 0.009 | 0.958 | 0.841–1.092 | 0.522 |
| Platelet count (1,000/µL) | 1.001 | 0.999–1.003 | 0.351 | |||
| Albumin (g/dL) | 0.566 | 0.399–0.804 | 0.001 | 0.651 | 0.377–1.125 | 0.124 |
| Total cholesterol (mg/dL) | 0.999 | 0.996–1.002 | 0.441 | |||
| Triglyceride (mg/dL) | 1.000 | 0.998–1.001 | 0.907 | |||
| HDL (mg/dL) | 1.000 | 0.988–1.012 | 0.966 | |||
| LDL (mg/dL) | 0.998 | 0.994–1.003 | 0.398 | |||
| HbA1c (%) | 1.168 | 1.007–1.355 | 0.040 | 0.966 | 0.754–1.238 | 0.786 |
| Blood urine nitrogen (mg/dL) | 0.992 | 0.982–1.001 | 0.087 | |||
| Creatinine (mg/dL) | 0.950 | 0.898–1.004 | 0.070 | |||
| Uric acid (mg/dL) | 0.920 | 0.806–1.052 | 0.223 | |||
| Calcium (mg/dL) | 0.999 | 0.852–1.172 | 0.994 | |||
| Phosphorus (mg/dL) | 0.915 | 0.809–1.035 | 0.159 | |||
| Aluminum (µg/dL) | 1.183 | 1.005–1.394 | 0.044 | 1.062 | 0.875–1.289 | 0.541 |
| iPTH (pg/mL) | 1.000 | 0.999–1.000 | 0.679 | |||
| Transferrin saturation (%) | 0.458 | 0.113–1.863 | 0.275 | |||
| Ferritin (µg/L) | 1.000 | 1.000–1.000 | 0.144 | |||
| PD system (Fresenius Stay Safe) | 0.580 | 0.144–2.341 | 0.444 | |||
| PD modality (APD) | 1.297 | 0.878–1.916 | 0.191 | |||
| Daily dwell volume (L) | 1.031 | 0.951–1.118 | 0.455 | |||
| Icodextrin | 0.762 | 0.554–1.047 | 0.094 | |||
| Nutrineal | 1.364 | 0.863–2.562 | 0.269 | |||
| Dialysate dextrose (%) | 1.450 | 1.075–1.956 | 0.015 | 1.251 | 0.825–1.899 | 0.292 |
| Dialysate calcium (2.5 mEq/L) | 0.953 | 0.708–1.282 | 0.750 | |||
| Dialysate/plasma creatinine | 7.680 | 2.037–28.954 | 0.003 | 0.883 | 0.125–6.218 | 0.901 |
| Weekly Kt/V urea (total) | 0.939 | 0.608–1.450 | 0.775 | |||
| Weekly CCr (normalized) | 0.993 | 0.982–1.005 | 0.235 | |||
| Cardiovascular event(s) | 1.853 | 1.331–2.579 | <0.001 | 1.539 | 1.014–2.337 | 0.043 |
| Infective episode(s) | 2.843 | 1.874–4.312 | <0.001 | 2.047 | 1.279–3.276 | 0.003 |
| Malignancy | 1.478 | 0.941–2.323 | 0.090 | |||
| EPS | 2.519 | 1.497–4.237 | <0.001 | 2.313 | 1.192–4.488 | 0.013 |
Abbreviations: HR, hazard ratio; CI, confidence interval; HS-CRP, high-sensitivity C-reactive protein; DM, diabetes mellitus; CAD, coronary artery disease; CHF, congestive heart failure; SLE, systemic lupus erythematosus; PD, peritoneal dialysis; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycated hemoglobin; iPTH, intact parathyroid hormone; APD, automated peritoneal dialysis; CCr, creatinine clearance; EPS, encapsulating peritoneal sclerosis.