Table 1.
Bone histomorphometry
| 6 weeks |
12 weeks |
|||
|---|---|---|---|---|
| Control | ΔACVR2A | Control | ΔACVR2A | |
| BV/TVa | 5.09 ± 0.28 | 6.28 ± 0.57b | 7.87 ± 0.57 | 9.99 ± 0.77b |
| Tb.Th | 18.56 ± 0.48 | 20.88 ± 1.14 | 22.83 ± 0.90 | 25.70 ± 1.14b |
| Tb.Sp | 356.18 ± 22.68 | 323.32 ± 19.59 | 275.55 ± 16.18 | 239.75 ± 14.45b |
| OV/BV | 0.99 ± 0.23 | 0.86 ± 0.07 | 0.33 ± 0.05 | 0.51 ± 0.07b |
| OS/BS | 4.17 ± 0.74 | 3.48 ± 0.27 | 2.54 ± 0.42 | 3.18 ± 0.38 |
| O.Th | 2.28 ± 0.25 | 2.53 ± 0.19 | 1.60 ± 0.15 | 2.06 ± 0.09b |
| N.Ob/BS | 254.44 ± 39.35 | 237.30 ± 79.45 | 144.80 ± 39.62 | 170.88 ± 65.61 |
| Ob.S/BS | 3.68 ± 0.51 | 2.98 ± 0.90 | 2.11 ± 0.60 | 2.44 ± 1.07 |
| ES/BS | 2.96 ± 0.61 | 3.18 ± 0.52 | 2.15 ± 0.42 | 2.83 ± 0.62 |
| E.De | 5.52 ± 0.46 | 4.23 ± 0.27b | 3.95 ± 0.64 | 4.15 ± 0.36 |
| N.Oc/BS | 95.43 ± 16.49 | 112.08 ± 19.95 | 75.73 ± 14.79 | 93.24 ± 20.41 |
| Oc.S/BS | 2.83 ± 0.64 | 3.00 ± 0.53 | 2.13 ± 0.42 | 2.74 ± 0.61 |
| MAR | 2.04 ± 0.13 | 1.71 ± 0.06b | 1.13 ± 0.07 | 1.11 ± 0.07 |
| dLS/BS | 9.77 ± 0.83 | 10.07 ± 1.17 | 10.65 ± 0.95 | 12.60 ± 1.68 |
| sLS/BS | 7.18 ± 0.61 | 8.70 ± 1.27 | 5.97 ± 0.34 | 5.55 ± 0.66 |
| MS/BS | 13.36 ± 0.96 | 14.42 ± 1.44 | 13.64 ± 1.07 | 15.37 ± 1.83 |
| BFR/BS | 3.85 ± 0.37 | 3.41 ± 0.30 | 3.21 ± 0.35 | 3.43 ± 0.46 |
| Omt | 1.17 ± 0.15 | 1.47 ± 0.08b | 1.47 ± 0.16 | 1.90 ± 0.13b |
| Mlt | 0.37 ± 0.08 | 0.37 ± 0.04 | 0.26 ± 0.04 | 0.49 ± 0.13b |
a Histomorphometry was performed in trabecular bone of the distal femur in ΔACVR2A male mice. BV/TV, bone volume/tissue Volume (%); Tb.Th, trabecular thickness (mm); Tb.Sp, trabecular spacing (mm); OV/BV, osteoid volume/bone volume (%); OS/BS, osteoid surface/bone surface (%); O.Th, osteoid thickness (mm); N.Ob/BS, osteoblast number/bone surface (no./100 mm); Ob.S/BS, osteoblast surface/bone surface (%); ES/BS, erosion surface/bone surface (%); E.De, erosion depth (mm); N.Oc/BS, osteoclast number/bone surface (no./100 mm); Oc.S/BS, osteoclast surface/bone surface (%); MAR, mineral apposition rate (day); dLS/BS, double labeled surface/bone surface (%); sLS/BS, single labeled surface/bone surface (%); MS/BS, mineralizing surface/bone surface (%); BFR/BS, bone formation rate/bone surface (μm3/μm2/day); Omt, osteoid maturation time (day); Mlt, mineralization lag time (day). Values shown are mean ± S.E.
b p < 0.05 versus age-matched control.