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. 2017 Aug 21;7:8390. doi: 10.1038/s41598-017-08273-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Competitive ELISA with VHH and known mAbs on optC and ZM197M SOSIPs. On optC (upper part), CD4bs ligands compete with VHH-9, VHH-23, VHH-43, A6, less with VHH-28 and VHH-1; on ZM197M (lower part), CD4bs ligands compete with A6, VHH-43, VHH-5, VHH-23, less/not with VHH-1, VHH-28, VHH-33. Detection of competition also depends on strength of VHH binding to the respective SOSIP (see Supplementary Figure S5: VHH-9 does not bind ZM197M −> no competition detectable). Stars indicate competition, see also legend to Supplementary Table S2.