Table 1.
Neurophysiological Measures.
| Visit-A | Visit-B | ΔB-A | |ΔB-A| | |
|---|---|---|---|---|
| Mean ±SD | Mean ±SD | Mean ±SD | Mean ±SD | |
| Motor threshold (% MSO) | ||||
| RMT monophasic | 63.08 ± 13.4 | 65.00 ± 13.8 | 1.92 ± 4.6 | 3.86 ± 3.1 |
| RMT biphasic | 45.03 ± 11.7 | 44.72 ± 10.5 | –0.31 ± 5.4 | 3.81 ± 3.8 |
| AMT biphasic | 43.97 ± 11.6 | 43.83 ± 10.0 | –0.20 ± 6.6 | 4.26 ± 5.1 |
| Baseline MEPs (mV) | ||||
| Monophasic | 0.91 ± 0.9 | 0.89 ± 1.0 | 0.00 ± 0.8 | 0.48 ± 0.6 |
| Biphasic | 1.35 ± 1.0 | 1.30 ± 1.1 | –0.05 ± 1.1 | 0.74 ± 0.8 |
| Paired-pulse (%Δ)† | ||||
| SICI | –23.06 ± 65.2 | –12.36 ± 59.0 | 10.70 ± 59.0 | 41.42 ± 42.8 |
| LICI | –49.73 ± 77.6 | –67.21 ± 47.6 | –17.48 ± 74.4 | 34.64 ± 68.0 |
| ICF | 118.64 ± 203.0 | 145.36 ± 341.6 | 26.73 ± 368.4 | 166.55 ± 328.4 |
| Post-iTBS (%Δ)†† | ||||
| 5 min post-iTBS | 13.56 ± 51.3 | 27.50 ± 71.3 | 13.94 ± 75.5 | 53.61 ± 54.2 |
| 10 min post-iTBS | 11.81 ± 46.4 | 10.97 ± 51.9 | –0.83 ± 66.1 | 47.56 ± 45.3 |
| 20 min post-iTBS | –10.11 ± 43.1 | 18.44 ± 62.5 | 28.56 ± 64.0 | 51.33 ± 47.1 |
| 30 min post-iTBS | –0.41 ± 43.2 | 6.78 ± 60.2 | 7.15 ± 66.2 | 48.26 ± 45.0 |
| 40 min post-iTBS | 7.94 ± 53.6 | 20.61 ± 98.0 | 12.67 ± 92.9 | 63.11 ± 68.5 |
| 50 min post-iTBS | –3.31 ± 49.0 | 12.36 ± 80.3 | 16.37 ± 90.5 | 58.66 ± 70.2 |
| Maximum facilitation | 52.22 ± 52.5 | 85.31 ± 98.1 | 33.08 ± 93.6 | 62.53 ± 76.6 |
| Area under-the-curve (%Δ∗time)†† | ||||
| 0–20 min post-iTBS | 105.28 ± 690.4 | 313.06 ± 901.9 | 206.08 ± 948.1 | 711.64 ± 649.4 |
| 0–50 min post-iTBS | 47.71 ± 1609.9 | 738.89 ± 2529.1 | 737.57 ± 2422.6 | 1759.91 ± 1800.2 |
ΔB–A, net inter-visit difference; |ΔB–A|, absolute inter-visit difference; MSO, maximum stimulator output; RMT, resting motor threshold; AMT, active motor threshold; MEPs, motor evoked potentials; SICI, short-interval intracortical inhibition; LICI, long-interval intracortical inhibition; ICF, intracortical facilitation. †Percent change calculated from monophasic baseline; ††percent change calculated from biphasic baseline.