Anxiety-related behaviors in EPM of Wistar (WIS) and Wistar Kyoto (WKY) female rats at P 60 during diestrus (D1 + D2) and proestrus-estrus phases (P + E) of estrous cycle. a Open arm duration. ** Significant differences between WIS and WKY during proestrus-estrus phases (P + E) of estrous cycle, p < 0.01, t = 3.374. $$$ Significant difference in Wistars during diestrus (D1 + D2) and proestrus-estrus phase (P + E) − p < 0.001, t = 6.142. b Open arm entries. * Significant differences between WIS and WKY during proestrus-estrus phases (P + E) of estrous cycle, p < 0.05, t = 3.093. $$ Significant difference in Wistars during diestrus (D1 + D2) and proestrus-estrus phase (P + E) − p < 0.01, t = 3.214.