Table 1.

Anxiety-related profiles of late adolescent Wistar and WKY rats in elevated plus maze during different phases of the estrous cycle

Variables	D1 + D2		P + E
	WIS	WKY	WIS	WKY
Time, %
Open arm	14.16±1.08	15.28±4.91	45.18±4.10$$$	25.28±2.37**
Closed arm	69.26±5.04	83.83±4.66	32.92±2.48$$$	51.99±4.83*, $$$
Entries, %
Open arm	41.87±3.67	28.88±2.11	60.10±2.77$$	42.55±6.64*
Closed arm	55.76±3.43	71.12±2.11**	42.28±1.69$	66.30±5.63***
Anxiety index	0.71±0.02	0.79±0.03	0.49±0.03$$$	0.67±0.06**
Locomotion, m	16.33±1.68	16.15±1.63	20.24±2.02	19.87±2.74
Ethological parameters, n
Nose dips	7.17±0.75	6.80±0.86	11.43±1.29$	7.17±0.87*
Rearings	10.00±1.08	24.40±3.12***	14.20±1.07	14.50±1.44$$
Stretch-attend postures	1.80±0.20	2.75±0.25	0.33±0.21$$	3.25±0.48**

Data are expressed as mean ± SEM. n = 6 in each group. One-way ANOVA.

^*Indicates significant differences between the strains – Wistar (WIS) and Wistar Kyoto (WKY) during diestrus (D1 + D2) and proestrusestrus (P + E) phases of estrous cycle.

^**Indicates significant differences between the strains – Wistar (WIS) and Wistar Kyoto (WKY) during diestrus (D1 + D2) and proestrusestrus (P + E) phases of estrous cycle.

^***Indicates significant differences between the strains – Wistar (WIS) and Wistar Kyoto (WKY) during diestrus (D1 + D2) and proestrusestrus (P + E) phases of estrous cycle.

^$Indicates significant differences in the same strain during diestrus (D1 + D2) and proestrus-estrus (P + E) phases of estrous cycle. p < 0.05, p < 0.01, p < 0.001.

^$$Indicates significant differences in the same strain during diestrus (D1 + D2) and proestrus-estrus (P + E) phases of estrous cycle. p < 0.05, p < 0.01, p < 0.001.

^$$$Indicates significant differences in the same strain during diestrus (D1 + D2) and proestrus-estrus (P + E) phases of estrous cycle. p < 0.05, p < 0.01, p < 0.001.