Table 1.
Treatment results of radiotherapy for pediatric glioma
| Authors (year) | Number of patients | Follow-up | Radiotherapy | Additional treatment | Result | Late toxicity |
|---|---|---|---|---|---|---|
| Macdonald et al., 200520) | 76 (HGA) | - 56 died |
Photon; 59.4 Gy, 1.8 Gy / Fr | Chemo before RT Randomly assigned 3 protocols | 5y-OS 24% 5y-EFS 8% | 11 had grade 3 or 4 CNS toxicities. |
| Merchant et al., 200921) | 78 (LGG) | 89 months (28–137) | Photon; 54.0 Gy, 1.8 Gy / Fr | Chemo before RT (n = 25) Surgery (none 13, one 42, two 18, three 5) | 5y-OS 98.5%, 10y-OS 95.9% 5y-EFS 87.4%, 10y-EFS 74.3% | Vasculopathy 4.8% (7y) |
| Hug et al., 200224) | 27 (LGG) | 3.3 years (0.6–6.8) | Proton; 55.2 GyE (50.4–63.0) 1.8 GyE / Fr | 25 of 27 were unresectable or residual disease | OS 85% LC 78% | Moyamoya disease: 1 |
| Greenberger et al., 201425) | 32 (LGG) | 7.6 years (3.2–18.2) | Proton; 52.2 GyE (48.6–54.0) | Chemo before RT (n = 16) Surgery (none 5, biopsy only 6, one 17, two or more 4) | 8y-OS 100% 8y-PFS 82.8% | Vasculopathy: 2 |
Fr: fraction, HGA: high grade astrocytoma, LC: Local control, LGG: low grade glioma, 3 protocols: carboplatin/etoposide ifomide/etoposide cyclophosmide/etoposide, y-EFS: year event free survival, y-OS: year overall survival, y-PFS: year progression free survival.