. 2017 Jun 9;57(7):343–355. doi: 10.2176/nmc.ra.2017-0003

Table 4.

Treatment results of radiotherapy for pediatric intracranial germinoma

Authors (year)	Number of patients	Follow-up	Radiotherapy	Additional treatment	Result	Late toxicity
Bamberg et al., 1999⁷⁴⁾	60	118 months (30–180)	Photon; CSI 36 Gy + Focal 14 Gy (2 Gy / Fr) CSI 30 Gy + Focal 15 Gy (1.5 Gy / Fr)	RT alone	5y-OS 93.7% 5y-EFS 87.6%	23 patients had endocrine abnormality requiring hormone replacement.
Calaminus et al., 2013⁷⁰⁾	190	6 years (2.7–14)	Photon; CSI 24 Gy + Focal 16Gy (1.6 Gy / Fr)	RT alone	5y-OS 95% 5y-PFS 97%	-
Calaminus et al., 2013⁷⁰⁾	190	6 years (2.7–14)	Photon; Focal 40 Gy (1.6 Gy / Fr)	ICE	5y-OS 96% 5y-PFS 88%	-
Macdonald et al., 2011⁷⁷⁾	22	28 months (30–180)	Proton; Total dose 30.6–57.6 GyE CSI/WVRT 19.5–35 GyE Focal 50.4 (n = 1) WVRT + Focal (n = 8) CSI + Focal (n = 13)	ICE for NGGCT (9/9) Platinum based chemo for GCT (11/13)	OS 100% PFS 95%	-

CSI: craniospinal irradiation, Fr: fraction, ICE: ifosfamide + carboplatin + etoposide, NGGCT: nongerminomatous germ cell tumor, y-EFS: year event free survival, y-OS: year overall survival, y-PFS: year progression free survival.